Motor Neuron Disease (MND) is essentially a clinical syndrome which is from and composed of different neurodegenerative disorders. It involves the death of motor neurons in the cerebral cortex, brain stem, and spinal cord. This results in the non-functioning motor application of muscles bordering on immobility; respiratory and swallowing problems. The need for relief from illness has demanded purgation for treatment. Stem cell therapy has been discovered as one of the many options for curing the disease.
Stem Cell Treatment in India
At Stem Cell Cure, we harness the latest treatment methods to fight and cure this terrible malady. We would thus be reviewing what has so far been said and known about stem cell treatment and how the technique would work on rebuilding nerve cells in patients suffering from MND.
Understanding Stem Cells
Stem cells could basically be generalized as cells with specific properties which are mainly designed to constitute every type of cell in the human body. They may renew themselves as they divide and create other stem cells and develop into specialized cells, which include neurons. For this reason, they are the essence of tissue engineering application, which would be used in repairing damaged nerve cells.
Mechanisms of Stem Cell Therapy in MND
Stem cells are said to replace neuroprotective degenerated input motor neurons or help the surviving ones do better. This is in line with what stem cell therapy promises regarding the MND condition:
Cell Replacement: The replacement of dead or degenerating motor neurons forms the very basis of the application. Scientists have been working on a method for reprogramming stem cells into motor neuron-like stem cells for grafting into the spinal cord of patients. Post-implantation, these cells would actively make functional connections with other neurons replacing partially the motor functions of the damaged motor neuron.
Neuroprotection: There is also the possibility of forming neurotrophic factors since these factors would develop and also loss of neurons. The various growth factors and cytokines that these bridge carry help protect neurons from degeneration. This is certainly very important during the course of the disease when death after dural injury to motor neurons continues. With MND, the ongoing degenerating process is retarded since most of the neurons will be dead or degenerated.
Modulation of the Immune Response: In the case of MND, itself, inflammation has worsened the disease progression. When stem cells are mobilized with inflammation, it reduces the population of immune cells, which ultimately kill neuron cells and make the microenvironment safe for neuronal growth and regeneration.
Current Research and Innovation
Motor Neuron Disease
Latest studies have brought the new entry for application of the stem cells towards the cure of MND. For example, MSCs derived from bone marrow proved a safe and efficacious treatment against MND. Motor Neuron Disease treatment in india The other promising most exciting field currently has its concentration at the use of induced pluripotent stem cells (iPSCs). When converted into pluripotent adult cells, they can eventually be differentiated and turned into motor neurons. Therefore, in addition to being an alternative source for cell replacement therapy, it is also a modality to therapy augmentation.